Publications of ProtPath doctoral researchers
| 2024 |
Cosenza-Contreras M, Schäfer A, Sing J, Cook L, Stillger MN, Chen CY, Villacorta Hidalgo J, Pinter N, Meyer L, Werner T, Bug D, Haberl Z, Kübeck O, Zhao K, Stei S, Gafencu AV, Ionita R, Brehar FM, Ferrer-Lozano J, Ribas G, Cerdá-Alberich L, Martí-Bonmatí L, Nimsky C, Van Straaten A, Biniossek ML, Föll M, Cabezas-Wallscheid N, Büscher J, Röst H, Arnoux A, Bartsch JW, Schilling O. Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism. Neuro Oncol. 2024 Mar 4;26(3):488-502. doi: 10.1093/neuonc/noad208. PMID: 37882631; PMCID: PMC10912002. |
|
El Fakiri M, Regupathy AR, Uhlmann L, Ayada N, Geis NM, Domogalla LC, Lahdenranta J, Blakeman B, Wood F, Meyer PT, Huxley P, Eder M, Mudd GE, Eder AC. Development and preclinical characterization of a novel radiotheranostic EphA2-targeting bicyclic peptide. Theranostics 2024; 14(12):4701-4712. doi:10.7150/thno.96641. https://www.thno.org/v14p4701.htm |
|
|
Elsässer J, Kraft C. Synthetic Dimerization Approaches for In Vivo Studies in Saccharomyces cerevisiae. Methods Mol Biol. 2024;2845:27-37. doi: 10.1007/978-1-0716-4067-8_3. PMID: 39115655. |
|
|
Caceres L, Abogunloko T, Malchow S, Ehret F, Merz J, Li X, Sol Mitre L, Magnani N, Tasat D, Mwinyella T, Spiga L, Suchanek D, Fischer L, Gorka O, Colin Gissler M, Hilgendorf I, Stachon P, Rog-Zielinska E, Groß O, Westermann D, Evelson P, Wolf D, Marchini T. Molecular mechanisms underlying NLRP3 inflammasome activation and IL-1β production in air pollution fine particulate matter (PM2.5)-primed macrophages. Environ Pollut. 2024 Jan 15;341:122997. doi: 10.1016/j.envpol.2023.122997. PMID: 38000727 |
|
|
Cosenza-Contreras M, Seredynska A, Vogele D, Pinter N, Brombacher E, Cueto RF, Dinh TJ, Bernhard P, Rogg M, Liu J, Willems P, Stael S, Huesgen PF, Kuehn EW, Kreutz C, Schell C, Schilling O. TermineR: Extracting information on endogenous proteolytic processing from shotgun proteomics data. Proteomics. 2024 Aug 10:e2300491. doi: 10.1002/pmic.202300491. Epub ahead of print. PMID: 39126236. |
|
|
Eickhorst C*, Babic R*, Rush-Kittle J, Lucya L, Lami Imam F, Sánchez-Martín P, Hollenstein DM, Michaelis J, Münch C, Meisinger C, Slade D, Gámez-Díaz L, Kraft C. FIP200 phosphorylation regulates late steps in mitophagy. J Mol Biol. 2024 May 29:168631. doi: 10.1016/j.jmb.2024.168631. Epub ahead of print. PMID: 38821350. *equal contribution |
|
|
Zolg S, Donzelli L, Geiss-Friedlander R. N-terminal processing by dipeptidyl peptidase 9: Cut and Go! Biochimie. 2024 Mar 9:S0300-9084(24)00052-X. doi: 10.1016/j.biochi.2024.03.002. Epub ahead of print. PMID: 38461970. |
|
|
Busto JV, Ganesan I, Mathar H, Steiert C, Schneider EF, Straub SP, Ellenrieder L, Song J, Stiller SB, Lübbert P, Chatterjee R, Elsaesser J, Melchionda L, Schug C, den Brave F, Schulte U, Klecker T, Kraft C, Fakler B, Becker T, Wiedemann N. Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery. Cell Rep. 2024 Mar 26;43(3):113805. doi: 10.1016/j.celrep.2024.113805. Epub 2024 Feb 19. PMID: 38377000. |
|
|
Barz S, Hofmann K, Reggiori F, Kraft C. Beyond the C-terminal glycine of ATG8 proteins – The story of some neglected amino acids. Journal of Molecular Biology (2024), doi: https://doi.org/ |
|
| El Fakiri M, Ayada N, Müller M, Hvass L, Gamzov TH, Clausen AS, Geis NM, Steinacker N, Hansson E, Lindegren S, Aneheim E, Jensen H, Eder AC, Jensen AI, Poulie CBM, Kjaer A, Eder M, Herth MM. Development and Preclinical Evaluation of [211At]PSAt-3-Ga: An Inhibitor for Targeted α-Therapy of Prostate Cancer. J Nucl Med. 2024 Apr 1;65(4):593-599. doi: 10.2967/jnumed.123.267043. PMID: 38423784. | |
| Arbuznikova D, Klotsotyra A, Uhlmann L, Domogalla L-C, Steinacker N, Mix M, Niedermann G, Spohn SKB, Freitag MT, Grosu AL, Meyer PT, Gratzke C, Eder M, Zamboglou C, Eder A-C. Exploring the role of combined external beam radiotherapy and targeted radioligand therapy with [177Lu]Lu-PSMA-617 for prostate cancer – from bench to bedside. Theranostics 2024. Doi: 10.7150/thno.93249 | |
| Campos Alonso M, Knobeloch KP. In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases. Front Mol Biosci. 2024 Feb 22;11:1349509. doi: 10.3389/fmolb.2024.1349509. PMID: 38455765; PMCID: PMC10919355. | |
| Schneider J, Mitschke J, Bhat M, Vogele D, Schilling O, Reinheckel T, Heß L. Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover. Biochimie. 2024 Mar 28:S0300-9084(24)00071-3. doi: 10.1016/j.biochi.2024.03.013. Epub ahead of print. PMID: 38552867. | |
| Heß L, Aliar K, Grünwald BT, Griffin R, Lozan A, Knöller M, Khokha R, Brummer T, Reinheckel T. Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer. Biochim Biophys Acta Mol Basis Dis. 2024 Mar 25;1870(5):167133. doi: 10.1016/j.bbadis.2024.167133. Epub ahead of print. PMID: 38531482. | |
| 2023 | Arbuznikova D, Eder M, Grosu AL, Meyer PT, Gratzke C, Zamboglou C, Eder AC. Towards Improving the Efficacy of PSMA-Targeting Radionuclide Therapy for Late-Stage Prostate Cancer-Combination Strategies. Curr Oncol Rep. 2023 Nov;25(11):1363-1374. doi: 10.1007/s11912-023-01458-6. Epub 2023 Oct 20. PMID: 37861915; PMCID: PMC10640479. |
| Herzog AM, Göbel K, Marongiu L, Ruetalo N, Alonso MC, Leischner C, Busch C, Burkard M, Lauer UM, Geurink PP, Knobeloch KP, Schindler M, Fritz G, Venturelli S. Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication. Phytomedicine. 2024 Jan;123:155176. doi: 10.1016/j.phymed.2023.155176. Epub 2023 Oct 30. PMID: 37976697. | |
| de Maissin H, Groß PR, Mohiuddin O, Weigt M, Nagel L, Herzog M, Wang Z, Willing R, Reichardt W, Pichotka M, Heß L, Reinheckel T, Jessen HJ, Zeiser R, Bock M, von Elverfeldt D, Zaitsev M, Korchak S, Glöggler S, Hövener JB, Chekmenev EY, Schilling F, Knecht S, Schmidt AB. In Vivo Metabolic Imaging of [1-13 C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen. Angew Chem Int Ed Engl. 2023 Sep 4;62(36):e202306654. doi: 10.1002/anie.202306654. Epub 2023 Jul 25. PMID: 37439488. |
|
| Hollenstein DM, Maurer-Granofszky M, Reiter W, Anrather D, Gossenreiter T, Babic R, Hartl N, Kraft C, Hartl M. Chemical Acetylation of Ligands and Two-Step Digestion Protocol for Reducing Codigestion in Affinity Purification-Mass Spectrometry. J Proteome Res. 2023 Sep 15. doi: 10.1021/acs.jproteome.3c00424. Epub ahead of print. | |
| Bettecken A*, Heß L*, Hölzen L, Reinheckel T. Dipeptidyl-Aminopeptidases 8 and 9 Regulate Autophagy and Tamoxifen Response in Breast Cancer Cells. Cells. 2023; 12(16):2031. https://doi.org/10.3390/cells12162031 *equal contribution | |
| Donzelli L, Bolgi O, Geiss-Friedlander R. The amino-dipeptidyl peptidases DPP8 and DPP9: Purification and enzymatic assays. Methods Enzymol. 2023;684:289-323. doi: 10.1016/bs.mie.2023.02.013. Epub 2023 Mar 21. | |
| Sánchez-Martín P, Kriegenburg F, Alves L, Adam J, Elsaesser J, Babic R, Mancilla H, Licheva M, Tascher G, Münch C, Eimer S, Kraft C. ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy. J Cell Sci. 2023 Feb 1;136(3):jcs260546. doi: 10.1242/jcs.260546. Epub 2023 Feb 9. | |
| Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis. Sci Signal. 2023 Jan 17;16(768):eabh1083. doi: 10.1126/scisignal.abh1083. Epub 2023 Jan 17. DOI: 10.1126/scisignal.abh108 | |
| 2022 | Fröhlich K, Brombacher E, Fahrner M, Vogele D, Kook L, N. Pinter, Bornsert P, Timme-Bornsert S, Schmidt A, Bärenfaller K, Kreutz C, Schilling O. Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity. Nat Commun 13, 2622 (2022). https://doi.org/10.1038/s41467-022-30094-0 |
| Bolgi O, Silva-Garcia M, Ross B, Pilla E, Kari V, Killisch M, Spitzner M, Stark N, Lenz C, Weiss K, Donzelli L, Gorrell MD, Grade M, Riemer J, Urlaub H, Dobbelstein M, Huber R, Geiss-Friedlander R. Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO reports (2022) 23: e54136. https://doi.org/10.15252/embr.202154136 | |
| Carvalho LAR, Ross B, Fehr L, Bolgi O, Wöhrle S, Lum KM, Podlesainski D, Vieira AC, Kiefersauer R, Félix R, Rodriguez T, Lucas SD, Groß O, Geiss-Freidlander R, Cravatt BF, Huber R, Kaiser M, Moreira R. Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angew. Chem.Int. Ed.2022,61,e202210498. https://doi.org/10.1002/anie.202210498 | |
| 2021 | El Fakiri M, Geis NM, Ayada N, Eder M, Eder AC. PSMA-Targeting Radiopharmaceuticals for Prostate Cancer Therapy: Recent Developments and Future Perspectives. Cancers. 2021; 13(16):3967. https://doi.org/10.3390/cancers13163967 |
| Barz S, Kriegenburg F, Sánchez-Martín P, Kraft C. Small but mighty: Atg8s and Rabs in membrane dynamics during autophagy. BBA - Molecular Cell Research 1868 (2021) 119064. https://doi.org/10.1016/j.bbamcr.2021.119064 |