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Nora Vögtle

Vögtle, Nora
Dr. rer.nat.
Center for Molecular Biology of Heidelberg University (ZMBH)
Im Neuenheimer Feld 345, 69120 Heidelberg
n.voegtle[at]zmbh.uni-heidelberg.de
 
Current position

Full Professor, Center for Molecular Biology of Heidelberg University

 

 

 

Research topic in GRK 2606:  Proteases in mitochondrial protein quality control

University training and degree(s)
2002 − 2007     Studies in Molecular Medicine in Freiburg, Germany
 
Advanced academic qualifications
2007 − 2011      PhD, Institute of Biochemistry and Molecular Biology
 
Postgraduate professional career
since 2019        PI and Executive Board member in the CRC1381 Dynamic organization of cellular
                         protein machineries
since 2019        Associate investigator in the excellence cluster CIBSS Centre for Integrative Biological
                         Signalling Studies
since 2016        Emmy-Noether-group leader, Institute of Biochemistry and Molecular Biology,
                         University of Freiburg, Germany
2014 − 2016     Young group leader, fellowship of the Baden-Württemberg Stiftung (Postdoc Eliteprogramm),
                         Institute of Biochemistry and Molecular Biology, University of Freiburg, Germany
2011 − 2014     Postdoctoral fellow, Institute of Biochemistry and Molecular Biology,
                         University of Freiburg, Germany
 
Other
2014                 Short-term EMBO fellowship for Research Internship at the Institute for Molecular Biosciences,
                         University of Graz, Austria
2010 – 2011     Research Internship in the group of Prof. Mike Ryan, La Trobe University, Melbourne, Australia
 

10 important publications
# corresponding; *contributed equally
  1. Poveda-Huertes, D., Matic, S., Marada, A., Habernig, L., Licheva, M., Myketin, L., Gilsbach, R., Tosal-Castano, S., Papinski, D., Mulica, P., Kretz, O., Kücükköse, C., Taskin, A.A., Hein, L., Kraft. C., Büttner, S., Meisinger, C.*, Vögtle, F.N.* (2020). An early mtUPR: Redistribution of the nuclear transcription factor Rox1 into mitochondria protects against intramitochondrial proteotoxic aggregates. Mol. Cell 77, 180-188 *Corresponding authors
  2. Vögtle, F.N.#,*, Brändl, B.*, Larson, A.*, Pendziwiat, M.*, Friederich, M.W.*, White, S.M., Basinger, A., Kücükköse, C., Muhle, H., Jähn, J.A., Keminer, O., Helbig, K.L., Delto, C.F., Myketin, L., Mossmann, D., Burger, N., Miyake, N., Burnett, A., van Baalen, A., Lovell, M.A., Matsumoto, N., Walsh, M., Yu, H.C., Shinde, D.N., Stephani, U., Van Hove, J.L.K., Müller, F.J., Helbig, I.# (2018). Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood. Am. J. Hum. Genet. 102(4): 557-573.
  3. Taskin, A.A., Kücükköse, C., Burger, N., Mossmann, D., Meisinger, C., Vögtle, F.N. (2017). The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing. Mol. Biol. Cell 28(8): 997-1002.
  4. Eldomery, M.K.*, Akdemir, Z.C.*, Vögtle, F.N.*, Charng, W.L., Mulica, P., Rosenfeld, J.A., Gambin, T., Gu, S., Burrage, L.C., Al Shamsi, A., Penney, S., Jhangiani, S.N., Zimmerman, H.H., Muzny, D.M., Wang, X., Tang, J., Medikonda, R., Ramachandran, P.V., Wong, L.J., Boerwinkle, E., Gibbs, R.A., Eng, C.M., Lalani, S.R., Hertecant, J., Rodenburg, R.J., Abdul-Rahman, O.A., Yang, Y., Xia, F., Wang, M.C., Lupski, J.R., Meisinger, C., Sutton, V.R. (2016). MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death. Genome Med. 8(1): 106.
  5. Burkhart, J.M., Aras-Taskin, A., Zahedi, R.P., Vögtle, F.N. (2015). Quantitative profiling for substrates of the mitochondrial presequence processing protease reveals candidates of a proteotoxic stress response. J. Proteome Res. 14(11): 4550-4563.
  6. Vögtle, F.N.#, Keller, M., Aras-Taskin, A., Horvath, S.E., Guan, X.L., Prinz, C., Opalińska, M., Zorzin, C., van der Laan, M., Wenk, M.R., Schubert, R., Wiedemann, N., Holzer, M., Meisinger, C.# (2015).Mitochondrial dynamics: The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1. J. Cell Biol. 210(6): 951-960.
  7. Mossmann, D.*, Vögtle, F.N.*, Taskin, A.A., Teixeira, P.F., Ring, J., Burkhart, J.M., Burger, N., Pinho, C.M., Tadic, J., Loreth, D., Graff, C., Metzger, F., Sickmann, A., Kretz, O., Wiedemann, N., Zahedi, R.P., Madeo, F., Glaser, E., Meisinger, C. (2014). Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab. 20(4): 662-669.
  8. Vögtle, F.N.*, Burkhart, J.M.*, Rao, S., Gerbeth, C., Hinrichs, J., Martinou, J.C., Chacinska, A., Sickmann, A., Zahedi, R.P., Meisinger, C. (2012). Intermembrane space proteome of yeast mitochondria. Mol. Cell. Proteomics 11(12): 1840-1852.
  9. Vögtle, F.N., Prinz, C., Kellermann, J., Lottspeich, F., Pfanner, N., Meisinger, C. (2011). Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization. Mol. Biol. Cell 22(13): 2135-2143.
  10. Vögtle, F.N.*, Wortelkamp, S.*, Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N., Meisinger C. (2009). Global analysis of the mitochondrial N-Proteome identifies a processing peptidase critical for protein stability. Cell 139(2): 428-439.