Chris Meisinger

Meisinger, Chris

Prof. Dr. rer. nat,
Institute for Biochemistry and Molecular Biology, University of Freiburg
Stefan-Meier-Str. 17, D-79104 Freiburg
chris.meisinger[a]biochemie.uni-freiburg.de

Current position

Full Professor (W3) of Biochemistry, Institute for Biochemistry and Molecular Biology

Research topic in GRK 2606: Orphan proteases of mitochondria

University training and degree(s)

1987 − 1993 Study of Chemistry (Diploma), University of Freiburg. Diploma thesis on protein crystallization

(Prof. G.E. Schulz)

Advanced academic qualifications

2007 Habilitation in Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg

1993 - 1997 Dr. rer. nat., Faculty of Chemistry, University of Freiburg. Expression and regulation of fibroblast

growth factors in the nervous system (Prof. C. Grothe)

Postgraduate professional career

Since 2015 Full Professor (W3) at the Institute of Biochemistry and Molecular Biology, University of Freiburg

2009 – 2015 Professor (W2) at the Institute of Biochemistry and Molecular Biology and the Excellence Cluster

BIOSS (Centre for Biological Signalling Studies), University of Freiburg

2000 – 2009 Group leader, Institute for Biochemistry and Molecular Biology, University of Freiburg

1998 – 2000 Post Doc at the Institutes for Anatomy (Prof. B. Christ) and Biochemistry (Prof. N. Pfanner),

University of Freiburg

Other

Since 2019 Speaker of the SFB 1381 “Dynamic organization of cellular protein machineries”,

University of Freiburg

2017 Organizer of the 68^th Mosbacher Kolloquium of the GBM

2015 Offer for Professorship and Chair of Biochemistry,

University of Graz, Austria, declined

2012 Best lecturer in Molecular Medicine (evaluation by the B.S. students of Molecular Medicine)

2010-2012 Visiting research Professor (18 month), University of Bern, Switzerland

2008 Offer for Professorship (W3) and Chair of Physiological Chemistry,

University of Marburg, declined

2008 Offer for Professorship (W3) and Chair of Biochemistry,

University of Düsseldorf, declined

2008 Offer for Professorship (W2) of Physiological Chemistry, University of Mainz, declined

Since 2008 Project leader in the excellence cluster BIOSS, University of Freiburg

Since 2007 Project leader in the Spemann Graduate School of Biology and Medicine (SGBM); since 2012

member of the executive board

2007 1. NaT-Working award of the Robert-Bosch-Stiftung for collaboration between

University and schools

2005 Eugen-Graetz research award for discovery of the SAM-complex

Since 2003 Constant top ten position of best lecturers (annual evaluation by averagely 350 students of human

medicine)

10 important publications (*contributed equally)

Poveda-Huertes, D., Matic, S., Marada, A., Habernig, L., Licheva, M., Myketin, L., Gilsbach, R., Tosal-Castano, S., Papinski, D., Mulica, P., Kretz, O., Kücükköse, C., Taskin, A.A., Hein, L., Kraft. C., Büttner, S., Meisinger, C.*, Vögtle, F.N.* (2020). An early mtUPR: Redistribution of the nuclear transcription factor Rox1 into mitochondria protects against intramitochondrial proteotoxic aggregates. Mol. Cell 77, 180-188 *Corresponding authors
Vögtle, F.N., Burkhart, J.M., Gonczarowska-Jorge, H., Kücükköse, C., Taskin, A.A., Kopczynski, D., Ahrends, R., Mossmann, D., Sickmann, A., Zahedi, R.P., Meisinger, C. (2017). Landscape of submitochondrial protein distribution. Nat. Commun. 8, 290.
Krüger, V., Becker, T., Becker, L., Montilla-Martinez, M., Ellenrieder, L., Vögtle, F.N., Meyer, H.E., Ryan, M.T., Wiedemann, N., Warscheid, B., Pfanner, N., Wagner, R., Meisinger, C. (2017). Identification of new channels by systematic analysis of the mitochondrial outer membrane. J. Cell Biol. 216, 3485-3495.
Harbauer, A.B., Opalińska, M., Gerbeth, C., Herman, J.S., Rao, S., Schönfisch, B., Guiard, B., Schmidt, O., Pfanner, N., Meisinger, C. (2014). Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science 346,1109-1113.
Mossmann, D., Vögtle, F.N., Taskin, A.A., Teixeira, P.F., Ring, J., Burkhart, J.M., Burger, N., Pinho, C.M., Tadic, J., Loreth, D., Graff, C., Metzger, F., Sickmann, A., Kretz, O., Wiedemann, N., Zahedi, R.P., Madeo, F., Glaser E., Meisinger, C. (2014). Amyloid-b peptide induces mitochondrial dysfunction by inhibition of preprotein maturation.Cell Metab. 20, 662-669.
Gerbeth, C., Schmidt, O., Rao, S., Harbauer, A.B., Mikropoulou, D., Opalińska, M., Guiard, B., Pfanner, N., Meisinger, C. (2013). Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases. Cell Metab. 18, 578-587.
Schmidt, O., Harbauer, A.B., Rao, S., Eyrich, B., Zahedi, R.P., Stojanovski, D., Schönfisch, B., Guiard, B., Sickmann, A., Pfanner, N., Meisinger, C. (2011). Regulation of mitochondrial protein import by cytosolic kinases. Cell 144, 227-239.
Vögtle, F.N., Wortelkamp, S., Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N., Meisinger, C. (2009). Global analysis of the mitochondrial N-Proteome identifies a processing peptidase critical for protein stability. Cell 139, 428-439.
Wiedemann, N., Kozjak, V., Chacinska, A., Schönfisch, B., Rospert, S., Ryan, M.T., Pfanner, N., Meisinger, C. (2003). Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424, 565-571.
Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N. Meisinger, C. (2003).The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100, 13207-13212.