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Chris Meisinger

Meisinger, Chris
Prof. Dr. rer. nat,
Institute for Biochemistry and Molecular Biology, University of Freiburg
Stefan-Meier-Str. 17, D-79104 Freiburg
Current position
Full Professor (W3) of Biochemistry, Institute for Biochemistry and Molecular Biology





Research topic in GRK 2606: Orphan proteases of mitochondria


University training and degree(s)

1987 − 1993    Study of Chemistry (Diploma), University of Freiburg. Diploma thesis on protein crystallization
                       (Prof. G.E. Schulz)
Advanced academic qualifications
2007                Habilitation in Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg
1993 - 1997      Dr. rer. nat., Faculty of Chemistry, University of Freiburg. Expression and regulation of fibroblast
                       growth factors in the nervous system (Prof. C. Grothe)
Postgraduate professional career
Since 2015      Full Professor (W3) at the Institute of Biochemistry and Molecular Biology, University of Freiburg
2009 – 2015    Professor (W2) at the Institute of Biochemistry and Molecular Biology and the Excellence Cluster
                        BIOSS (Centre for Biological Signalling Studies), University of Freiburg
2000 – 2009    Group leader, Institute for Biochemistry and Molecular Biology, University of Freiburg
1998 – 2000    Post Doc at the Institutes for Anatomy (Prof. B. Christ) and Biochemistry (Prof. N. Pfanner), 
                        University of Freiburg
Since 2019      Speaker of the SFB 1381 “Dynamic organization of cellular protein machineries”,
                        University of Freiburg
2017                Organizer of the 68th Mosbacher Kolloquium of the GBM
2015                Offer for Professorship and Chair of Biochemistry,
                        University of Graz, Austria, declined
2012                Best lecturer in Molecular Medicine (evaluation by the B.S. students of Molecular Medicine)
2010-2012        Visiting research Professor (18 month), University of Bern, Switzerland
2008                Offer for Professorship (W3) and Chair of Physiological Chemistry,
                        University of Marburg, declined
2008                Offer for Professorship (W3) and Chair of Biochemistry,
                        University of Düsseldorf, declined
2008                Offer for Professorship (W2) of Physiological Chemistry, University of Mainz, declined
Since 2008       Project leader in the excellence cluster BIOSS, University of Freiburg
Since 2007       Project leader in the Spemann Graduate School of Biology and Medicine (SGBM); since 2012
                        member of the executive board
2007                1. NaT-Working award of the Robert-Bosch-Stiftung for collaboration between
                        University and schools
2005                Eugen-Graetz research award for discovery of the SAM-complex
Since 2003       Constant top ten position of best lecturers (annual evaluation by averagely 350 students of human
10 important publications (*contributed equally)
    1. Poveda-Huertes, D., Matic, S., Marada, A., Habernig, L., Licheva, M., Myketin, L., Gilsbach, R., Tosal-Castano, S., Papinski, D., Mulica, P., Kretz, O., Kücükköse, C., Taskin, A.A., Hein, L., Kraft. C., Büttner, S., Meisinger, C.*, Vögtle, F.N.* (2020). An early mtUPR: Redistribution of the nuclear transcription factor Rox1 into mitochondria protects against intramitochondrial proteotoxic aggregates. Mol. Cell 77, 180-188 *Corresponding authors
    2. Vögtle, F.N., Burkhart, J.M., Gonczarowska-Jorge, H., Kücükköse, C., Taskin, A.A., Kopczynski, D., Ahrends, R., Mossmann, D., Sickmann, A., Zahedi, R.P., Meisinger, C. (2017). Landscape of submitochondrial protein distribution. Nat. Commun. 8, 290.
    3. Krüger, V., Becker, T., Becker, L., Montilla-Martinez, M., Ellenrieder, L., Vögtle, F.N., Meyer, H.E., Ryan, M.T., Wiedemann, N., Warscheid, B., Pfanner, N., Wagner, R., Meisinger, C. (2017). Identification of new channels by systematic analysis of the mitochondrial outer membrane. J. Cell Biol. 216, 3485-3495.
    4. Harbauer, A.B., Opalińska, M., Gerbeth, C., Herman, J.S., Rao, S., Schönfisch, B., Guiard, B., Schmidt, O., Pfanner, N., Meisinger, C. (2014). Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science 346,1109-1113.
    5. Mossmann, D., Vögtle, F.N., Taskin, A.A., Teixeira, P.F., Ring, J., Burkhart, J.M., Burger, N., Pinho, C.M., Tadic, J., Loreth, D., Graff, C., Metzger, F., Sickmann, A., Kretz, O., Wiedemann, N., Zahedi, R.P., Madeo, F., Glaser E., Meisinger, C. (2014). Amyloid-b peptide induces mitochondrial dysfunction by inhibition of preprotein maturation.Cell Metab. 20, 662-669.
    6. Gerbeth, C., Schmidt, O., Rao, S., Harbauer, A.B., Mikropoulou, D., Opalińska, M., Guiard, B., Pfanner, N., Meisinger, C. (2013). Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases. Cell Metab. 18, 578-587.
    7. Schmidt, O., Harbauer, A.B., Rao, S., Eyrich, B., Zahedi, R.P., Stojanovski, D., Schönfisch, B., Guiard, B., Sickmann, A., Pfanner, N., Meisinger, C. (2011). Regulation of mitochondrial protein import by cytosolic kinases. Cell 144, 227-239.
    8. Vögtle, F.N., Wortelkamp, S., Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N., Meisinger, C. (2009). Global analysis of the mitochondrial N-Proteome identifies a processing peptidase critical for protein stability. Cell 139, 428-439.
    9. Wiedemann, N., Kozjak, V., Chacinska, A., Schönfisch, B., Rospert, S., Ryan, M.T., Pfanner, N., Meisinger, C. (2003). Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424, 565-571.
    10. Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N. Meisinger, C. (2003).The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100, 13207-13212.