Thomas Reinheckel

Reinheckel, Thomas

Prof. Dr. med.

Institute of Molecular Medicine and Cell Research, University of Freiburg

Stefan-Meier Str. 17, D-79104 Freiburg

email: thomas.reinheckel[a]mol-med.uni-freiburg.de

Current position

Full Professor (W3) of Molecular Medicine, Institute of Molecular Medicine and Cell Research

Research topic in GRK 2606: Proteases for essential lysosome functions

University training and degree(s)

1989-1996 Study of Medicine, University of Magdeburg and Albert Einstein College of Medicine, N.Y.C. USA

1993-1994 Academic year at the Dept. of Biochemistry and Molecular Biology; Albany N.Y. USA

Advanced academic qualifications

2007 Habilitation in Molecular Medicine, University of Freiburg

1997 Dissertation in Medicine, University of Magdeburg

Postgraduate professional career

Since 2013 Professor (W3) of Molecular Medicine / Cellular Pathomechanisms,

Institute of Molecular Medicine and Cell Research Freiburg

2002-2012 Group Leader; Institute of Molecular Medicine and Cell Research Freiburg

1999-2002 Postdoc; Institute of Molecular Medicine and Cell Research Freiburg

1996-1999 Internship / Residency Dept. of General Surgery, University Hospital Magdeburg

Other

since 2019 Member BIOSS Centre for Biological Signalling Studies Freiburg

since 2018 Member of foundation council of the FREY-WERLE endowment

since 2010 Board Member of SFB 850 - Control of Cell Motility in Morphogenesis, Cancer

Invasion and Metastasis, Freiburg

since 2008 Coordinator Curriculum BSc/MSc Program Molecular Medicine, Freiburg

since 2007 Principal Investigator Comprehensive Cancer Center Research Program - CCCF

2007-2019 Associate Member BIOSS Centre for Biological Signalling Studies Freiburg

since 2006 Principal Investigator Spemann Graduate School for Biology and Medicine-SGBM

2015-2017 President of the International Proteolysis Society (IPS)

2013-2015 Council Member and Vice President of the International Proteolysis Society

2011 Offer of a professorship of Biochemistry, Bonn

2011 Offer of a professorship of Biochemistry, Frankfurt

2007 Habilitation award by the Funds of Chemical Industry

1993-1994 Fellowship Biomedical Sciences Exchange Program between North America

and Europe

1991-1996 Fellowship of the Hans-Böckler-Foundation

10 important publications

Hillebrand, L.E., Wickberg, S.M., Gomez-Auli, A., Follo, M., Maurer, J., Busch, H., Boerries, M., Reinheckel, T. (2019). MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions. FASEB J. 33, 4124-4140.
Köhler, M., Ehrenfeld, S., Halbach, S., Lauinger, M., Burk, U., Reischmann, N., Cheng, S., Spohr, C., Uhl, F.M., Köhler, N., Ringwald, K., Braun, S., Peters, C., Zeiser, R., *Reinheckel, T., *Brummer, T. (2019). B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model. Oncogene 38, 1324-1339. *shared senior
Martínez-Fábregas, J., Prescott, A., van, Kasteren, S., Pedrioli, D.L., McLean, I., Moles, A., Reinheckel, T., Poli, V., Watts, C. (2018). Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. Nat. Commun. 9, 5343ff.
Kern, U., Wischnewski, V., Biniossek, ML., Schilling, O., Reinheckel, T. (2015). Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells. Mol. Cancer 14, 39ff.
Tholen, M., Hillebrand, L.E., Tholen, S., Sedelmeier, O., Arnold, S.J., Reinheckel, T. (2014). Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nat. Commun. 5, 4931-4941.
Bengsch, F., Buck, A., Gunther, S.C., Seiz, J.R., Tacke, M., Pfeifer, D., von, Elverfeldt, D., Sevenich, L., Hillebrand, L.E., Kern, U., Sameni, M., Peters, C., Sloane, B.F., Reinheckel, T. (2014). Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene 33, 4474-4484.
Sevenich, L., Schurigt, U., Sachse, K., Gajda, M., Werner, F., Muller, S., Vasiljeva, O., Schwinde, A., Klemm, N., Deussing, J., Peters, C., Reinheckel, T. (2010). Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc. Natl. Acad. Sci. U.S.A. 107, 2497-2502.
Reiser, J., Adair, B., Reinheckel, T. (2010). Specialized roles for cysteine cathepsins in health and disease J. Clin. Invest. 120, 3421-3431.
Vasiljeva, O., Papazoglou, A., Kruger, A., Brodoefel, H., Korovin, M., Deussing, J., Augustin, N., Nielsen, B.S., Almholt, K., Bogyo, M., Peters, C., Reinheckel, T. (2006). Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res. 66, 5242-5250.
10. Stypmann, J., Glaser, K., Roth, W., Tobin, D.J., Petermann, I., Matthias, R., Mönnig, G., Haverkamp, W., Breithardt, G., Schmahl, W., Peters, C., Reinheckel, T. (2002). Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc. Natl. Acad. Sci. U.S.A. 99, 6234-6239.