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Ruth Geiss-Friedlander

Geiss-Friedlander, Ruth
Dr. rer. nat.
Current position

Independent Group leader, Institute of Molecular Medicine and Cell Research, University of Freiburg




Research topic in GRK 2606: Proteases in cell signaling

University training and degree(s)
1994-1996       Study of Life Sciences, Ben-Gurion University, Beer-Sheva, Israel (B.Sc)
1997-1998       Study of Structural and Molecular Biochemistry, Hebrew University, Jerusalem, Israel (M.Sc)
Advanced academic qualifications
2004                 Dissertation in Biology and Biochemistry
                         Die Mathematisch-Naturwissenschaftliche-Fakultät I der Humboldt-Universität zu Berlin


Postgraduate professional career       
since 2020       Independent Research Group Leader, Institute of Molecular Medicine and Cell Research, 
                        University of Freiburg
2011-2020       Independent Research Group Leader, Department of Molecular Biology, University
                        Medical Centre, Göttingen                 
2009-2011       Associated Researcher, Department of Biochemistry I, University Medical Centre Göttingen
                        Biosciences (GGNB) program; Georg-August University of Göttingen
2004-2008       Postdoctoral Research Fellow in the laboratory of Professor Frauke Melchior,  Department of 
                        Biochemistry I, University Medical Centre Göttingen 


2019 - 2021     Elected Council Member and Vice President of the International Proteolysis Society
2018                Junior group in the Göttingen Center for Molecular Biosciences (GZMB)
2015                Associated member of the Göttingen Graduate School for Neurosciences and Molecular
                        Biosciences (GGNB) program; Georg-August University of Göttingen
2004                Doctor thesis was awarded a summa cum laude from the Humboldt University, Berlin
1996 - 1998     Recipient of a full scholarship by the Department of Structural and
                        Molecular Biochemistry, Hebrew University of Jerusalem, Israel (Master studies)

10 important publications
    1. Friedlander, R., Jarosch, E., Urban, J., Volkwein, C., Sommer, T. (2000). A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat. Cell Biol. 2, 379–384.
    2. Geiss-Friedlander, R., Melchior, F. (2007). Concepts in sumoylation: a decade on. Nat. Rev. Mol. Cell Biol. 8, 947–956.
    3. Geiss-Friedlander, R.*, Parmentier, N., Möller, U., Urlaub, H., Van den Eynde, B.J., Melchior, F.* (2009). The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides. J. Biol. Chem. 284, 27211–27219. * corresponding authors
    4. Pilla, E., Möller, U., Sauer, G., Mattiroli, F., Melchior, F., Geiss-Friedlander, R. (2012). A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation. J. Biol. Chem. 287, 44320–44329.
    5. Pilla, E., Kilisch, M., Lenz, C., Urlaub, H., Geiss-Friedlander, R. (2013). The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. J. Biol. Chem. 288, 32787–32796.
    6. Justa-Schuch, D., Möller, U., Geiss-Friedlander, R. (2014). The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. Cell. Mol. Life Sci. 71, 3611–3626.
    7. Kunadt, M., Eckermann, K., Stuendl, A., Gong, J., Russo, B., Strauss, K., Rai, S., Kügler, S., Lockhart, L.F., Schwalbe, M., Krumova, P., Oliveira, L.M.A., Bähr, M., Möbius, W., Levin, J., Giese, A., Kruse, N., Mollenhauer, B., Geiss-Friedlander, R. Ludolph, A.C., Freischmidt, A., Feiler, M.S., Danzer, K.M., Zweckstetter, M., Jovin, T.M., Simons, M., Weishaupt, J.H., Schneider, A., (2015). Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathol. 129, 695–713.
    8. Strenzke, N., Chakrabarti, R., Moyed, Al, H., Müller, A., Hoch, G., Pangrsic, T., Yamanbaeva, G., Lenz, C., Pan, K.-T., Auge, E., Geiss-Friedlander, R. Urlaub, H., Brose, N., Wichmann, C., Reisinger, E., (2016). Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants. EMBO J. 35, 2519–2535.
    9. Justa-Schuch, D., Silva-Garcia, M., Pilla, E., Engelke, M., Kilisch, M., Lenz, C., Möller, U., Nakamura, F., Urlaub, H., Geiss-Friedlander, R. (2016). DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk. eLife 5, e16370. doi:10.7554/eLife.16370
    10. Ross, B., Krapp, S., Augustin, M., Kierfersauer, R., Arciniega, M., Geiss-Friedlander, R., Huber, R. (2018). Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A. 115, E1437–E1445.