Ruth Geiss-Friedlander
Geiss-Friedlander, Ruth
Dr. rer. nat.
Institute of Molecular Medicine and Cell Research, University of Freiburg
ruth.geiss-friedlander[a]mol-med.uni-freiburg.de
Current position
Independent Group leader, Institute of Molecular Medicine and Cell Research, University of Freiburg
Research topic in GRK 2606: Proteases in cell signaling
University training and degree(s)
1994-1996 Study of Life Sciences, Ben-Gurion University, Beer-Sheva, Israel (B.Sc)
1997-1998 Study of Structural and Molecular Biochemistry, Hebrew University, Jerusalem, Israel (M.Sc)
Advanced academic qualifications
2004 Dissertation in Biology and Biochemistry
Die Mathematisch-Naturwissenschaftliche-Fakultät I der Humboldt-Universität zu Berlin
Postgraduate professional career
since 2020 Independent Research Group Leader, Institute of Molecular Medicine and Cell Research,
University of Freiburg
2011-2020 Independent Research Group Leader, Department of Molecular Biology, University
Medical Centre, Göttingen
2009-2011 Associated Researcher, Department of Biochemistry I, University Medical Centre Göttingen
Biosciences (GGNB) program; Georg-August University of Göttingen
2004-2008 Postdoctoral Research Fellow in the laboratory of Professor Frauke Melchior, Department of
Biochemistry I, University Medical Centre Göttingen
Other
2023 - 2025 Elected Council member and President of the International Proteolysis society (IPS)
2019 - 2021 Elected Council Member and Vice President of the International Proteolysis Society
2018 Junior group in the Göttingen Center for Molecular Biosciences (GZMB)
2015 Associated member of the Göttingen Graduate School for Neurosciences and Molecular
Biosciences (GGNB) program; Georg-August University of Göttingen
2004 Doctor thesis was awarded a summa cum laude from the Humboldt University, Berlin
1996 - 1998 Recipient of a full scholarship by the Department of Structural and
Molecular Biochemistry, Hebrew University of Jerusalem, Israel (Master studies)
10 important publications
- Friedlander, R., Jarosch, E., Urban, J., Volkwein, C., Sommer, T. (2000). A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat. Cell Biol. 2, 379–384.
- Geiss-Friedlander, R., Melchior, F. (2007). Concepts in sumoylation: a decade on. Nat. Rev. Mol. Cell Biol. 8, 947–956.
- Geiss-Friedlander, R.*, Parmentier, N., Möller, U., Urlaub, H., Van den Eynde, B.J., Melchior, F.* (2009). The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides. J. Biol. Chem. 284, 27211–27219. * corresponding authors
- Pilla, E., Möller, U., Sauer, G., Mattiroli, F., Melchior, F., Geiss-Friedlander, R. (2012). A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation. J. Biol. Chem. 287, 44320–44329.
- Pilla, E., Kilisch, M., Lenz, C., Urlaub, H., Geiss-Friedlander, R. (2013). The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9. J. Biol. Chem. 288, 32787–32796.
- Justa-Schuch, D., Möller, U., Geiss-Friedlander, R. (2014). The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. Cell. Mol. Life Sci. 71, 3611–3626.
- Kunadt, M., Eckermann, K., Stuendl, A., Gong, J., Russo, B., Strauss, K., Rai, S., Kügler, S., Lockhart, L.F., Schwalbe, M., Krumova, P., Oliveira, L.M.A., Bähr, M., Möbius, W., Levin, J., Giese, A., Kruse, N., Mollenhauer, B., Geiss-Friedlander, R. Ludolph, A.C., Freischmidt, A., Feiler, M.S., Danzer, K.M., Zweckstetter, M., Jovin, T.M., Simons, M., Weishaupt, J.H., Schneider, A., (2015). Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. Acta Neuropathol. 129, 695–713.
- Strenzke, N., Chakrabarti, R., Moyed, Al, H., Müller, A., Hoch, G., Pangrsic, T., Yamanbaeva, G., Lenz, C., Pan, K.-T., Auge, E., Geiss-Friedlander, R. Urlaub, H., Brose, N., Wichmann, C., Reisinger, E., (2016). Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants. EMBO J. 35, 2519–2535.
- Justa-Schuch, D., Silva-Garcia, M., Pilla, E., Engelke, M., Kilisch, M., Lenz, C., Möller, U., Nakamura, F., Urlaub, H., Geiss-Friedlander, R. (2016). DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk. eLife 5, e16370. doi:10.7554/eLife.16370
- Ross, B., Krapp, S., Augustin, M., Kierfersauer, R., Arciniega, M., Geiss-Friedlander, R., Huber, R. (2018). Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A. 115, E1437–E1445.