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Olaf Groß

Olaf Groß
Groß, Olaf
Prof. Dr. rer. nat.
Institute of Neuropathology, Medical Center – University of Freiburg
Breisacher Straße 64, D-79106 Freiburg
 olaf.gross[a]uniklinik-freiburg.de
 
Current position
Full Professor (W3), Institute of Neuropathology, Medical Center – University of Freiburg

 

 

 
University training and degree(s)
1997 − 2003   Studies in Biology, Technische Universität München (Diplom-Biologe)
 
Advanced academic qualifications
2015               Habilitation (Venia Legendi) in Molecular Medicine, Technische Universität München
2003 − 2008   Dissertation, Technische Universität München (Dr. rer. nat.)
 
Postgraduate professional career
since 2017       Full Professor, Institute of Neuropathology, Medical Center – University of Freiburg
2012 − 2017    Independent Research Group Leader, Klinikum rechts der Isar, Technische Universität München
2008 − 2012    Postdoctoral Research Fellow in the laboratory of Professor Jürg Tschopp, Département de
                        Biochimie, Université de Lausanne, Switzerland
 
Other
since 2015      Co-Organizer of the annual Autumn School Current Concepts in Immunology of the German
                       Society for Immunology (DGfI)
since 2014      Starting Grant of the European Research Council (awarded in 2013)
2012 – 2017   Independent Junior Research Group funding within the Bavarian Research Network for
                       Molecular Biosystems (BioSysNet)
2009 – 2011   EMBO long-term Fellowship
2009               Robert-Koch Post-Doctoral Award in Immunology
2006               Young Scientist Award of the German Society for Hematology and Oncology (DGHO)
 
10 important publications
*these authors contributed equally
  1. Schneider, K.S., Groß, C.J., Dreier, R.F., Saller, B.S., Mishra, R., Gorka, O., Heilig, R., Meunier, E., Dick, M.S., Ćiković, T., Sodenkamp, J., Médard, G., Naumann, R., Ruland, J., Kuster, B., Broz, P., Groß, O. (2017). The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. Cell Rep. 21, 3846-3859.
  2. Groß, CJ*, Mishra R*., Schneider KS., Médard G., Wettmarshausen J., Dittlein DC., Shi H., Gorka O., Koenig P.A., Fromm S., Magnani G., Cikovic T., Hartjes L., Smollich J., Robertson, A.A.B., Cooper, M.A., Schmidt-Supprian, M., Schuster, M., Schroder, K., Broz, P., Traidl-Hoffmann C., Beutler, B.,10 Kuster, B., Ruland, J., Schneider, S., Perocchi, F., Groß, O. (2016). K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity 45, 761-773.
  3. Höckendorf, U.*, Yabal, M.*, Herold, T., Munkhbaatar, E., Rott, S., Jilg, S., Kauschinger, J., Magnani, G., Reisinger, F., Heuser, M., Kreipe, H., Sotlar, K., Engleitner, T., Rad, R., Weichert, W., Peschel, C., Ruland, J., Heikenwalder, M., Spiekermann, K., Slotta-Huspenina, J., Groß, O., Jost, PJ. (2016). RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells. Cancer Cell 30, 75-91.
  4. Neumann, K., Castiñeiras-Vilariño, M., Höckendorf, U., Hannesschläger, N., Lemeer, S., Kupka, D., Meyermann, S., Lech, M., Anders, H.J., Kuster, B., Busch, D.H., Gewies, A., Naumann, R., Groß, O., Ruland, J. (2014). Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Immunity 40, 389-99.
  5. Groß, O*, Yazdi, A.S.*, Thomas, C.J., Masin, M., Heinz, LX., Guarda, G., Quadroni, M., Drexler, SK., Tschopp, J. (2012). Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36(3):388-400.
  6. Poeck, H.*, Bscheider, M.*, Groß, O.*, Finger, K., Roth, S., Rebsamen, M., Hannesschlager, N., Schlee, M., Rothenfusser, S., Barchet, W., Kato, H., Akira, S., Inoue, S., Endres, S., Peschel, C., Hartmann, G., Hornung, V., Ruland, J. (2010). Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat. Immunol. 11, 63-69
  7. Werninghaus, K.*, Babiak, A.*, Groß, O.*, Holscher, C., Dietrich, H., Agger, EM., Mages, J., Mocsai, A., Schoenen, H., Finger, K., Nimmerjahn, F., Brown, GD., Kirschning, C., Heit, A., Andersen, P., Wagner, H., Ruland, J., Lang, R. (2009). Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J. Exp. Med. 206, 89-97
  8. Groß, O.*, Poeck, H.*, Bscheider, M., Dostert, C., Hannesschlager, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V., Mocsai, A., Tschopp, J., Ruland, J. (2009). Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 459, 433-436
  9. LeibundGut-Landmann, S., Groß, O., Robinson, MJ., Osorio, F., Slack, EC., Tsoni, SV., Schweighoffer, E., Tybulewicz, V., Brown, GD., Ruland, J., Reis e Sousa, C. (2007). Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 8, 630-638
  10. Groß, O., Gewies, A., Finger, K., Schafer, M., Sparwasser, T., Peschel, C., Forster, I., Ruland, J. (2006). Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442, 651-656