Georg Häcker

Häcker, Georg

Prof. Dr. med.
Institute for Microbiology and Hygiene, Medical Center - University of Freiburg
Hermann-Herder-Str. 4, D-79104 Freiburg
georg.haecker[a]uniklinik-freiburg.de

Current position

Head of institute

Research topic in GRK 2606: Novel caspase functions

University training and degree(s)

1984 − 1990 Medical School, University Ulm (Human Medicine)

1990 Medical Examination

Advanced academic qualifications

1991 Doctoral degree (Dr. med., University of Ulm)

1998 Habilitation in Medical Microbiology and Immunology, Technische Universität München (TUM)

2002 Specialist Examination (Medical Microbiology, Virology and Epidemiology of Infectious Diseases)

(Bavarian College of Medical Doctors)

Postgraduate professional career

1991 – 1993 Resident Doctor/ Scientist, Institute for Medical Microbiology, TUM

(including 18 month-training phase as Arzt im Praktikum)

1992 Approbation (Licence to practise as a medical doctor)

1993 - 1995 DFG Training Fellowship at the Walter and Eliza Hall Institute for Medical

Research (WEHI) in Melbourne.

1995 Visiting Scientist, WEHI

1996 - 2000 Doctor/Scientist (group leader), Institute for Medical Microbiology, TUM

1998 - 2000 Privatdozent (Lecturer), Institute for Medical Microbiology, TUM

1997 - 2009 Consultant (Medical Microbiology) to the University Hospital of the TUM

2000 - 6/2009 C3-Professor, Institute for Medical Microbiology, Immunology and Hygiene,

Technical University Munich

Since 7/2009 W3-professor and Head, Department of Medical Microbiology and Hygiene,

University of Freiburg, Germany

Other

2010-2014 Managing Director of the Institute (as of 2013), Speaker of the Department of

Medical Microbiology and Hygienie,Medical Center - University of Freiburg, Germany

Since 2010 Elected Member of the Fakultätsrat, Medical Faculty, Freiburg University

Since 2014 Committee for Habilitation and Professional Appointments, Medical Faculty

2014 - 2018 Vice President, Deutsche Gesellschaft für Hygiene und Mikrobiologie

Since 2018 President, Deutsche Gesellschaft für Hygiene und Mikrobiologie

2008 Bachelor of Laws (LL.B.), University of London

10 important publications

Häcker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Wang, G., Kamps, M.P., Saha, S.K., Oganesyan, G., Raz, E., Wagner, H., Häcker, G., Mann, M., Cheng, G. and Karin, M. (2006). Specificity in TLR Signaling: Activation of the Interferon Response Depends on TRAF3. Nature 439, 204-207.
Bauer, A., Villunger, A., Labi, V., Fischer, S.F., Erlacher, M., Strasser, A., Wagner, H., Schmid R.M., Häcker, G. (2006). The NF-B regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc. Natl. Acad. Sci. U.S.A. 103, 10979-84
Weber, A., Paschen, S. A., Heger, K., Wilfling, F., Frankenberg, T., Bauerschmitt, H., Seiffert, B. M., Kirschnek, S., Wagner, H., Häcker, G. (2007). BimS Induced Apoptosis Requires Mitochondrial Localization but not Interaction with Anti-Apoptotic Bcl-2 Proteins. J. Cell Biol. 177, 625-36.
Paschen, S., Christian, J.G., Vier, J., Schmidt, F., Walch, A. Ojcius, D.M., Häcker, G. (2008) Cytopathicity of Chlamydia infection can be largely reproduced by expressing a single chlamydial gene, Chlamydial Protesase-like Activity Factor. J. Cell Biol. 182, 117-27
Feoktistova, S., Geserick, P., Kellert, B, Panayotova Dimitrova, D., Langlais, C., Hupe, M., Cain, K., MacFarlane, M., Häcker, G., Leverkus, M. (2011). cIAPs block Ripoptosome formation, a RIP1/caspase 8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43, 449-63.
Gentle, I.E., Moelter, I., Lechler, N., Bambach, S., Vucikuja, S., Häcker, G.*, Aichele, P.* (2014) Inhibitor of Apoptosis Proteins are required for effective T cell expansion/survival during anti-viral immunity in mice. Blood 123, 659-68. *Equal contribution.
Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A., Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., Schmitt-Graeff, A., Freudenberg, M., von Loewenich, F. D., Wolf, P., Leonhardt, F., Baxan, N., Pfeifer, D., Schmah, O., Schönle, A:, Martin, S. F., Mertelsmann, R., Duyster, J., Finke, J., Prinz, M., Henneke, P, Häcker, H., Hildebrandt, G. C.*, Häcker, G.*, Zeiser, R.* (2014) Neutrophil granulocytes recruited upon translocation of intestinal commensal bacteria enhance graft- versus-host disease via local tissue damage. Nat. Med. 20, 648-54. *Equal contribution.
Weber, A., Heinlein, M., Dengjel, J., Alber, C., Singh, P. K., Häcker, G. (2016). The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and can enhance apoptosis. EMBO Rep. 17, 724-38.
Singh, P.K., Roukounakis, A., Frank, D.O., Kirschnek, S., Das, K.K., Neumann, S., Madl, J., Römer, W., Zorzin, C., Borner, C., Haimovici, A., Garcia-Saez, A., Weber, A.*, Häcker, G.* (2017). Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilise Mcl-1 and regulate apoptosis. Genes Dev. 31, 1754-1769. *Joint senior authorship.
Brokatzky, D., Dörflinger, B., Haimovici, A., Weber, A., Kirschnek, S., Vier, J., Metz, A., Henschel, J., Steinfeldt, T., Gentle, I.E., Häcker, G. (2019). A non-death function of the mitochondrial apoptosis apparatus in immunity. EMBO J. 38, pii: e100907. doi: 10.15252/embj.2018100907.