Klaus-Peter Knobeloch

Knobeloch, Klaus-Peter

Priv. Doz. Dr. rer.nat.
Institute of Neuropathology, University of Freiburg
Breisacher Str. 64, D-79106 Freiburg
klaus-peter.knobeloch[a]uniklinik-freiburg.de

Current position

Independent research group leader, Institute of Neuropathology, University Freiburg, Medical Faculty

Research topic in GRK 2606: Deubiquinating enzymes in cell regulation

University training and degree(s)

1988-1994 Studies in Biology in Würzburg, Germany (Diplom-Biologe)

Advanced academic qualifications

2018 Habilitation (Venia Legendi) in Experimental Medicine, University of Freiburg

1995-2000 PhD Free University of Berlin and Leibniz Institute for Molecular Pharmacology (FMP), Berlin

Postgraduate professional career

1996-2000 FMP Head of transgenic facility (targeted mutagenesis))

2001-2002 Scientific Director for target validation/identification at Genpat Pharmacogenomics AG

2003-2008 Research Group leader (Principal investigator) AG “Cytokine Signaling” at the Leibniz Institute

for Molecular Pharmacology (FMP), Berlin

since 2008 Research Group leader (Principal investigator) AG “Molecular Genetics”,

Institute of Neuropathology, University of Freiburg, Germany

10 important publications

Basters., A., Geurink, P., Röcker, A., Witting, K.F., Ovaa, H., Knobeloch, K.P*., Fritz, G*. (2017). Structural basis for the specificity of USP18 towards ISG15. Nat. Struct. Mol. Biol. 24, 270-278 *Senior-/Corresponding authors.
Torre, S., Polyak, M., Langlais, D., Fodil, N., Kennedy, J.M., Radovanovic, I., Berghout, J., Leiva-Torres, G., Krawczyk, C., Ilangumaran, S., Mossman, K., Liang, C., Knobeloch, K.P., Healy, L., Antel, J., Arbour, N., Prat, A., Majewski, J., Lathrop, M., Vidal, S.M., Gros, P. (2017). USP15 regulates type I interferon response in vivo and is required for pathogenesis of microbial and autoimmune neuroinflammation. Nat. Immunol. 18, 54-63.
Klein-Hessling, S., Rudolf, R., Muhammad, K., Knobeloch, K.P., Maqbool, MA., Cauchy, P., Andrau, JC., Avots, A., Talora, C., Ellenrieder, V., Screpanti, I., Serfling, E., Patra, AK. (2016). A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development. Nat. Commun. 7, 11841ff.
Radoshevich, L., Impens, F., Ribet, D., Quereda, J.J., Nam, Tham, T., Nahori, M.A., Bierne, H., Dussurget, O., Pizarro-Cerdá, J., Knobeloch, K.P., Cossart, P. (2015) ISG15 counteracts Listeria monocytogenes infection Elife 4, doi: 10.7554/eLife.06848.
Dufner, A., Kisser, A., Niendorf, S., Basters, A., Reissig, S., Schönle, A., Aichem, A., Kurz, T., Schlosser, A., Yablonski, D., Groettrup, M., Buch, T., Waisman, A., Schamel, WW., Prinz, M., Knobeloch, K.P. (2015). The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Nat. Immunol. 16, 950-60.
Goldmann, T., Zeller, N., Raasch, J., Kierdorf, K., Frenzel, K., Ketscher, L., Basters, A., Staszewski, O., Brendecke, S., Spieß, A,Tay, T., Kreutz, C., Timmer, J., Mancini, G., Blank, T., Fritz, G., Biber, K., Lang, R., Malo, D., Merkler, D., Heikenwalder, M.,Knobeloch, K.P.*, Prinz, M.* (2015). Lack of microglial USP18 causes a destructive interferonopathy of the mouse brain. EMBO J. 34, 1612-29. *equal contribution.
Albert, GI., Schell, C., Kirschner, KM., Schäfer, S., Naumann, R., Müller, A., Kretz, O., Kuropka, B., Girbig, M., Hübner, N., Krause, E., Scholz, H., Huber, T.B., Knobeloch, K.P*., Freund, C*. (2015). The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function. J. Mol. Cell Biol. 7, 402-14. *equal contribution
Ketscher, L., Hannß, R., Morales, D.J., Basters, A., Guerra, S., Goldmann, T., Hausmann, A., Prinz, M., Naumann, R., Pekosz, A., Utermöhlen, O., Lenschow, D.J., Knobeloch, K.P. (2015). Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance. Proc. Natl. Acad. Sci. U.S.A. 112, 1577-82.
Begitt, A., Droescher, M., Meyer, T., Schmid, C.D., Baker, M., Antunes, F., Knobeloch, K.P., Owen, M.R., Naumann, R., Decker, T., Vinkemeier, U. (2014). STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling Nat. Immunol. 15, 168-76.

Educational material:

Klaus-Peter Knobeloch,Tim Hochgrebe, Kai Schuh: Stryer Biochemie Spiel. Spektrum Akademischer Verlag; ISBN-10: 3827400872 Auflage: 1 (1996). ISBN-13: 978-3827400871 Auflage: 2(1997).